Risk factors for toxicity in elderly patients given aminoglycosides once daily
نویسندگان
چکیده
منابع مشابه
An emotional-based medicine approach to monitoring once-daily aminoglycosides.
As the concepts of evidence-based health care become entwined into pharmacy practice, it is interesting to watch the use and monitoring of once-daily aminoglycosides (ODA) evolve. Many years ago, the monitoring of aminoglycoside serum concentrations was an inroad that allowed us, as hospital pharmacists, to get up on the wards and become directly involved in patient care. Fortunately, this prac...
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BACKGROUND People with cystic fibrosis, who are chronically colonised with the organism Pseudomonas aeruginosa, often require multiple courses of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations. The properties of aminoglycosides suggest that they could be given in higher doses less often. This is an update of a previously published review. OBJECTIVES To as...
متن کاملA meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses.
We performed a meta-analysis of randomised clinical studies in which the efficacy and toxicity of the same total daily dose of aminoglycosides administered once-daily was compared with multiple divided daily dosing for treating human infections. Of twenty-eight publications identified from a literature search using Medline 19 publications of 20 study comparisons involving 2881 patients met the ...
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Despite the therapeutic equivalence between twice-daily and once-daily tacrolimus, patient safety after conversion is still a concern. We reviewed 218 liver transplantation (LT) patients who converted twice-daily to once-daily tacrolimus between May 2011 and January 2014. Thirty (13.8%) patients had adverse events after conversion, with a liver function test (LFT) abnormality being the most com...
متن کاملOnce-daily dosing of aminoglycosides: review and recommendations for clinical practice.
The use of higher-dose, extended interval (i.e., once-daily) aminoglycoside regimens to optimize bacterial killing is justified by a pharmacodynamic principle of aminoglycosides, namely concentration-dependent killing, and by the partial attribution of the toxicity of aminoglycosides to prolonged serum concentrations. Numerous in-vitro and animal studies have supported using once-daily aminogly...
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ژورنال
عنوان ژورنال: Journal of General Internal Medicine
سال: 1998
ISSN: 0884-8734,1525-1497
DOI: 10.1046/j.1525-1497.1998.00224.x